| Description | HDAC6-IN-6 (compound 6a) is a potent inhibitor of HDAC6 that can penetrate BBB with an IC50 value of 0.025 μM. HDAC6-IN-6 has potent inhibitory activity against AChE and Aβ 1-42 self-aggregation with IC50 values of 0.72 and 3.0 μM. HDAC6-IN-6 can enhance the outgrowth of neurite without significant neurotoxicity [1]. |
| In vitro | HDAC6-IN-6 (compound 6a) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC 50 values of 7.96 and 8 μM, respectively [1] |
| molecular weight | 329.35 |
| Molecular formula | C20H15N3O2 |
| CAS | 2413603-10-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |