| Description | HDAC1/MAO-B-IN-1 has the potential to be used in the Alzheimer’s disease research. HDAC1/MAO-B-IN-1 is a potent and selective inhibitor of HDAC1/MAO-B that can cross the blood-brain barrier. The IC50 values of HDAC1/MAO-B-IN-1 for HDAC1 and MAO-B are 21.4 nM and 99.0 nM, respectively [1]. |
| In vitro | HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC 50 s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively [1]. HDAC1/MAO-B-IN-1 (50 μM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells [1]. Cell Viability Assay [1] Cell Line: PC12 cells Concentration: 50 μM Incubation Time: 24 h Result: Displayed neuroprotective and inhibitory activity on ROS production. |
| In vivo | HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability [1]. HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice [1]. Animal Model: 6-8 weeks, ICR male mice [1] Dosage: 20 mg/kg Administration: I.g. Result: Exhibited favorable BBB (blood–brain barrier) permeability. Animal Model: 20-25 g, ICR female mice [1] Dosage: 15 mg/kg Administration: I.p.; 15 consecutive days Result: Improved the learning and memory abilities of the ICR mice. |
| molecular weight | 328.79 |
| Molecular formula | C18H17ClN2O2 |
| CAS | 2759855-37-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |