| Description | HDAC/Top-IN-1 is a broad-spectrum, orally active dual HDAC/Top inhibitor that acts on HDAC1 (IC50: 0.036 μM), HDAC2 (IC50: 0.14 μM), HDAC3 (IC50: 0.059 μM), HDAC6 (IC50: 0.089 μM) and HDAC8 ( IC50: 9.8 μM). HDAC/Top-IN-1 was able to block HEL cells in S-phase and effectively induce apoptosis. |
| molecular weight | 512.53 |
| Molecular formula | C29H25FN4O4 |
| CAS | 2411379-14-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |