| Description | HDAC-IN-27 是一种有效的口服活性 HDAC I 类选择性抑制剂，对 HDAC1-3 的 IC 50 值范围为 0.43 至 3.01 nM。抗急性髓系白血病 (AML) 活性。 |
| In vitro | In wt-p53 MV4-11 cells, HDAC-IN-27 (11h) leads to pro-caspase-3 cleavage, apparent apoptotic cell death, and accumulation of sub-G1 cell population while inducing G2/M arrest in HL60 cells with no evidence of apoptosis [1]. |
| molecular weight | 350.41 |
| Molecular formula | C20H22N4O2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |