| Description | HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) is a CatSper channel modulator. |
| Target activity | CatSper channel:3 µM |
| Synonyms | HC 056456, 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide |
| molecular weight | 306.32 |
| Molecular formula | C12H6N2O4S2 |
| CAS | 7733-96-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 150 mg/mL (489.68 mM) |
| References | 1. Carlson AE, Burnett LA, del Camino D, Quill TA, Hille B, Chong JA, Moran MM, Babcock DF. Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One. 2009 Aug 31;4(8):e6844. |
| Citations | 1. Zhang J, Gao M, Niu Y, et al. Identification of a Novel Ferroptosis Inducer for Gastric Cancer Treatment Using Drug Repurposing Strategy. Frontiers in Molecular Biosciences. 2022, 9. |