| Description | HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner. |
| In vitro | HBT1以谷氨酸依赖的方式与AMPA-R的配体结合域(LBD)结合。HBT1与LY451395结合到AMPA-R LBD中一个口袋的模式有所不同：HBT1与LBD中的S518形成了氢键。HBT1较低的激动剂特性可能与其在初级神经元中产生BDNF的钟形反应的较低风险有关。 |
| molecular weight | 386.39 |
| Molecular formula | C16H17F3N4O2S |
| CAS | 489408-02-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.87 mg/mL (10 mM) |
| References | 1. Kunugi A , Tajima Y , Kuno H , et al. HBT1, a novel AMPA receptor potentiator with lower agonistic effect, avoided bell-shaped response in in vitro BDNF production[J]. Journal of Pharmacology & Experimental Therapeutics, 2018:jpet.117.245050. |