| Description | H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, H-D-Phe-Pip-Arg-pNA dihydrochloride is employed for the quantification of antithrombin-heparin cofactor (AT-III). The AT-III assay utilizing this substrate is characterized by its sensitivity, accuracy, and ease of implementation. |
| Synonyms | S-2238 dihydrochloride, H-D-Phe-Pip-Arg-pNA dihydrochloride |
| molecular weight | 625.55 |
| Molecular formula | C27H38Cl2N8O5 |
| CAS | 62354-65-8 |
| Storage | keep away from moisture|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 125 mg/mL (199.82 mM) DMSO: 125 mg/mL (199.82 mM), Sonication is recommended. |
| References | 1. Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647. 2. Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353. |
H-D-Phe-Pip-Arg-pNA dihydrochloride
CAS No.: 62354-65-8
H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of
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