| Description | GW280264X (Carbamic acid) is an inhibitor of ADAM17 . |
| Target activity | ADAM10:11.5 nM (IC50), ADAM17:8 nM (IC50) |
| Synonyms | Carbamic acid |
| molecular weight | 575.72 |
| Molecular formula | C28H41N5O6S |
| CAS | 866924-39-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 11 mg/mL (19.11 mM) |
| References | 1. Malemud C J . Inhibition of MMPs and ADAM/ADAMTS[J]. Biochemical Pharmacology, 2019. 2. J Yang, Leblanc M E , Cano I , et al. ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface[J]. Journal of Biological Chemistry, 2020. |