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Gue1654

CAS No.: 397290-30-1

Gue1654 is a modulator of oxoeicosanoid receptor 1 (OXE-R). Gue1654 selectively inhibits Gβγ upon activation of the G
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Description Gue1654 is a modulator of oxoeicosanoid receptor 1 (OXE-R). Gue1654 selectively inhibits Gβγ upon activation of the Gαi-βγ heterotrimer by OXE-R. Gue1654 inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.
Synonyms Gue-1654, Gue 1654
molecular weight 447.6
Molecular formula C23H17N3OS3
CAS 397290-30-1
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
References 1. Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie JP, Reinero CR, Rokach J, Powell WS. Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. Biochem Pharmacol. 2015 Aug 1;96(3):247-55. doi: 10.1016/j.bcp.2015.05.009. PubMed PMID: 26032638; PubMed Central PMCID: PMC4830392. 2. Konya V, Blättermann S, Jandl K, Platzer W, Ottersbach PA, Marsche G, Gütschow M, Kostenis E, Heinemann A. A biased non-Gαi OXE-R antagonist demonstrates that Gαi protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE. J Immunol. 2014 May 15;192(10):4774-82. doi: 10.4049/jimmunol.1302013. PubMed PMID: 24733850. 3. Blättermann S, Peters L, Ottersbach PA, Bock A, Konya V, Weaver CD, Gonzalez A, Schröder R, Tyagi R, Luschnig P, Gäb J, Hennen S, Ulven T, Pardo L, Mohr K, Gütschow M, Heinemann A, Kostenis E. A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer. Nat Chem Biol. 2012 Jul;8(7):631-8. doi: 10.1038/nchembio.962. PubMed PMID: 22634634.