| Description | GSK3787 is a specific and irreversible PPARδ inhibitor（pIC50= 6.6）. |
| In vivo | Pparβ/δ-null mice are administered GSK3787 (10 mg/kg) by oral gavage 3 hours before euthanasia. |
| Target activity | PPARδ:6.6(pIC50) |
| molecular weight | 392.78 |
| Molecular formula | C15H12ClF3N2O3S |
| CAS | 188591-46-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 40 mg/mL (101.84 mM), Sonication is recommended. |
| References | 1. Shearer BG, et al. J Med Chem, 2010, 53(4), 1857-1861. 2. Palkar PS, et al. Mol Pharmacol, 2010, 78(3) 419-430. 3. Brown PJ, et al. Chem Biol, 1997, 4(12), 909-918. |
| Citations | 1. Han W, Wang N, Kong R, et al. Ligand-activated PPARδ expression promotes hepatocellular carcinoma progression by regulating the PI3K-AKT signaling pathway. Journal of Translational Medicine. 2022, 20(1): 1-14. |