| Description | GSK2292767 FA is a potent and selective inhibitor of PI3Kδ (pIC50 : 10.1).GSK2292767 FA is more than 500-fold more selective than other PI3K isoforms.GSK2292767 FA can be used in the study of respiratory diseases. |
| In vivo | GSK2292767 in a brown Norwegian rat acute OVA model of Th2 driven pulmonary inflammation in rats 35 μg/kg of ED50 protects eosinophil recruitment.[1]In rat PK studies, GSK2292767 showed a high clearance rate (50 mL/min/kg) and low oral bioavailability (F<2%) in vivo.[1] |
| Synonyms | GSK2292767 FA(1254036-66-2 Free base) |
| molecular weight | 558.61 |
| Molecular formula | C25H30N6O7S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Down K, et al. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease. J Med Chem. 2015;58(18):7381-7399. |