| Description | GSK1482160 is a potent and selective P2X7 receptor allosteric modulator. |
| Synonyms | GSK 1482160, GSK-1482160 |
| molecular weight | 334.72 |
| Molecular formula | C14H14ClF3N2O2 |
| CAS | 1695551-19-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Han J, Liu H, Liu C, Jin H, Perlmutter JS, Egan TM, Tu Z. Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response. Nucl Med Commun. 2017 May;38(5):372-382. doi: 10.1097/MNM.0000000000000660. PubMed PMID: 28338530; PubMed Central PMCID: PMC5401628. 2. Territo PR, Meyer JA, Peters JS, Riley AA, McCarthy BP, Gao M, Wang M, Green MA, Zheng QH, Hutchins GD. Characterization of (11)C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation. J Nucl Med. 2017 Mar;58(3):458-465. doi: 10.2967/jnumed.116.181354. Epub 2016 Oct 20. PubMed PMID: 27765863. 3. Gao M, Wang M, Green MA, Hutchins GD, Zheng QH. Synthesis of [(11)C]GSK1482160 as a new PET agent for targeting P2X(7) receptor. Bioorg Med Chem Lett. 2015 May 1;25(9):1965-70. doi: 10.1016/j.bmcl.2015.03.021. Epub 2015 Mar 14. PubMed PMID: 25819093. 4. Solini A, Usuelli V, Fiorina P. The dark side of extracellular ATP in kidney diseases. J Am Soc Nephrol. 2015 May;26(5):1007-16. doi: 10.1681/ASN.2014070721. Epub 2014 Dec 1. Review. PubMed PMID: 25452669; PubMed Central PMCID: PMC4413770. |