| Description | GSK-B, a potent γ-secretase modulator, decreases Aβ42, increases Aβ38 with no effect on Aβ40 levels. |
| molecular weight | 515.53 |
| Molecular formula | C27H31F6NO2 |
| CAS | 884599-96-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Cheng Z, Zhang J, Liu H, Li Y, Zhao Y, Yang E. Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis- and Alzheimer's disease-related animal models despite reported blood-brain barrier disruption. Drug Metab Dispos. 2010 Aug;38(8):1355-61. doi: 10.1124/dmd.110.033324. Epub 2010 Apr 28. PubMed PMID: 20427691. 2. Pal R, Khanna A. Role of smad- and wnt-dependent pathways in embryonic cardiac development. Stem Cells Dev. 2006 Feb;15(1):29-39. PubMed PMID: 16522160. |