| Description | GSK 3008348 hydrochloride is an integrin αvβ6 antagonist. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for GSK 3008348 is 8.1, whereas its affinity in the cell Adhesion Assays was for ανβ6 (pIC50: 8.4); ανβ3 (pIC50: 6); ανβ5 (pIC50: 6.9); ανβ8 (pIC50: 7.7). |
| Target activity | αvβ6:(pIC50)8.4 |
| molecular weight | N/A |
| Molecular formula | C29H37N5O2.xHCl |
| CAS | 1629249-40-6 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 11.66 mg/mL, Sonication and heating are recommended. |
| References | 1. Anderson Niall Andrew, et al. Preparation of naphthyridine derivatives useful as αvβ6 integrin antagonists. From PCT Int. Appl. (2014), WO 2014154725 A1 20141002. |