| Description | GSK-114 is a selective inhibitor of TNNI3 interacting kinase (TNNI3K) with an IC50 of 25 nM, 40-fold significant bias for TNNI3K compared to B-Raf with an IC50 of 1000 nM, so GSK-114 has excellent Broad-spectrum kinase selectivity and sufficient oral exposure enable use in cellular and in vivo studies. |
| Target activity | TNNI3K:25 nM |
| molecular weight | 417.48 |
| Molecular formula | C19H23N5O4S |
| CAS | 1301761-96-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 5.5 mg/mL (13.17 mM), Sonication is recommended. |
| References | 1. Brian G. Lawhorna, Joanne Philpa, et al. GSK114: A selective inhibitor for elucidating the biological role of TNNI3K. Bioorganic & Medicinal Chemistry Letters. Volume 26, Issue 14, 15 July 2016, Pages 3355-3358 |