| Description | GS 389 is a novel tetrahydroisoquinoline analog with vasorelaxant properties. GS-389 significantly inhibited cGMP phosphodiesterase from the rabbit brain and increased cGMP levels in the rat aorta. |
| Synonyms | GS-389, GS389 |
| molecular weight | 313.39 |
| Molecular formula | C19H23NO3 |
| CAS | 41498-37-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Chang KC, Chong WS, Lee IJ. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994 Apr;72(4):327-34. PubMed PMID: 7922863. 2. Chang KC, Lim JK, Park CW. Pharmacological evaluation of GS-389, a novel tetrahydroisoquinoline analog related to higenamine, on vascular smooth muscle. Life Sci. 1992;51(1):67-74. PubMed PMID: 1614275. |