| Description | GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) is a chemotactic receptor known for its role in the maturation of B cells, and the endogenous ligand is the oxysterol 7α,25-dihydroxycholesterol (7α,25-OHC). GPR183 can be used in research on inflammatory bowel disease (IBD). |
| Synonyms | 3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide |
| molecular weight | 364.36 |
| Molecular formula | C19H19F3N2O2 |
| CAS | 1241280-25-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (137.22 mM) |
| References | 1. Misselwitz B, et al. The oxysterol receptor GPR183 in inflammatory bowel diseases. Br J Pharmacol. 2021 Aug;178(16):3140-3156. 2. Braden K, et al. GPR183-Oxysterol Axis in Spinal Cord Contributes to Neuropathic Pain. J Pharmacol Exp Ther. 2020 Nov;375(2):367-375. |