| Description | GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. |
| In vitro | 在MDH耦联GOT1酶活性测定中，GOT1 inhibitor-1对GOT1活性显示出抑制作用，其IC50为8.2 μM[1]。 |
| Target activity | GOT1:8.2 μM |
| Synonyms | GOT1 inhibitor 2c |
| molecular weight | 354.83 |
| Molecular formula | C19H19ClN4O |
| CAS | 732973-87-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 120 mg/mL (338.19 mM), Sonication is recommended. |
| References | 1. Anglin J , Zavareh R B , Sander P N , et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma[J]. Bioorganic & Medicinal Chemistry Letters, 2018:S0960894X18303743. |