| Description | Glycopyrronium tosylate an anticholinergic compound used in the treatment of axillary hyperhidrosis for the study of a variety of cryptobacterial tumors. |
| In vivo | Glycopyrronium tosylate (GT) 在降低汗液的严重性和产量方面，相比安慰剂有显著效果，并且整体耐受性良好。GT与安慰剂相比，在每一个研究周的改善均显著更大，特别是在第4周，ASDD评分从基线开始，分别在严重性、影响和困扰度方面提高了62.6%对比34.0%、65.5%对比40.3%、及65.4%对比39.0%。此外，使用GT相比安慰剂在WI项目、PGIC、HDSS和DLQI方面也显示出优势。[2] |
| molecular weight | 326.58 |
| Molecular formula | C12H9BrClN3O |
| CAS | 1624259-25-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (137.79 mM) |
| References | 1. Yokozeki H, et al. Topical glycopyrronium tosylate in Japanese patients with primary axillary hyperhidrosis: A randomized, double-blind, vehicle-controlled study. J Dermatol. 2022;49(1):86-94. 2. Pariser DM, et al. Topical Glycopyrronium Tosylate for the Treatment of Primary Axillary Hyperhidrosis: Patient-Reported Outcomes from the ATMOS-1 and ATMOS-2 Phase III Randomized Controlled Trials. Am J Clin Dermatol. 2019;20(1):135-145. 3. Pariser DM, et al. Limited Systemic Exposure with Topical Glycopyrronium Tosylate in Primary Axillary Hyperhidrosis. Clin Pharmacokinet. 2021;60(5):665-676. |