| Description | Glycerol phenylbutyrate-D15 is a deuterium-labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand (pKi: 8.02). |
| In vivo | Glycerol phenylbutyrate (GPB) may have therapeutic potential in additional conditions such as chronic hepatic encephalopathy or other inherited metabolic disorders.Glycerol phenylbutyrate (GPB) has the potential for the treatment of hyperammonemia. |
| Synonyms | HPN-100-D15 |
| molecular weight | 545.74 |
| Molecular formula | C33H23D15O6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Rescifina A, et al. Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis. Eur J Pharm Sci. 2017 Aug 30;106:94-101. 2. Oishi K, et al. Glycerol phenylbutyrate for the chronic management of urea cycle disorders. Expert Rev Endocrinol Metab. 2014 Sep;9(5):427-434. |