| Description | Glutamate-5-kinase-IN-2 (compound 54) exhibits G5K inhibition by promotes conformational changes at the L-glutamate binding site that is a potent glutamate-5-kinase (G5K) inhibitor with an MIC of 4.2 μM. Glutamate-5-kinase-IN-2 has the potential for anti-TB research [1]. |
| In vitro | Glutamate-5-kinase-IN-2 (compound 54) (40 μM) inhibits G5K activity with an I 0.5 of 33 μM at 10 mM concentration of L-Glu and ATP [1]. Glutamate-5-kinase-IN-2 (5, 10, 20 μM) shows no relevant cytotoxicity in HepG2 cells [1]. |
| molecular weight | 296.73 |
| Molecular formula | C17H10ClFN2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |