| Description | GLUT4-IN-2 is a specific GLUT4 inhibitor that inhibits GLUT1 and GLUT4.GLUT4-IN-2 has antitumor activity, induces apoptosis and cell cycle arrest, and can be used for cancer research. |
| In vitro | 在 CME、K562、KCL-22、MB-231、HS-27 细胞中，GLUT4-IN-2（1-100 µM；48小时）表现出强大的细胞毒性，其对 CME、K562、KCL-22、MB-231、HS-27 细胞的半数细胞毒性浓度（CC50）分别为1.7、91.9、15.3、45.1、44.0 µM[1]。 |
| In vivo | 在 8-10 周龄的 SCID 小鼠（CEM 异种移植瘤模型）中，GLUT4-IN-2（50 mg/kg；腹腔注射；在第 1-5 天、第 8-12 天、第 15-18 天给予）显示出强大的体内抗肿瘤活性[1]。 |
| Target activity | MDA-MB-231 cells:45.1 µM （CC50）, GLUT1:11.4 μM, GLUT4:6.8 μM, HS-27:44.0 µM （CC50）, K562:91.9 µM （CC50）, CME:1.7 µM, KCL-22:15.3 µM （CC50） |
| molecular weight | 385.42 |
| Molecular formula | C17H11N3O4S2 |
| CAS | 2454113-83-6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (207.57 mM), Sonication is recommended. |
| References | 1. Tilekar K,et al. Structure guided design and synthesis of furyl thiazolidinedione derivatives as inhibitors of GLUT 1 and GLUT 4, and evaluation of their anti-leukemic potential. Eur J Med Chem. 2020 Sep 15;202:112603. |