| Description | Glufosinate ammonium is a phosphinic acid analogue of glutamic acid and is an herbicide. Glufosinate ammonium is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium has neurotoxic activity. |
| In vitro | 草铵禾灭生降低室管膜细胞合成纤毛的能力。草铵禾灭生（1-100 μM；12DIV）在100 μM浓度下明显减少Celsr2基因的表达。草铵禾灭生（1-100 μM；12DIV）破坏V-SVZ区域分化的神经干细胞（NSCs）之间的细胞-细胞粘附[2]。 |
| In vivo | Glufosinate ammonium（10-250 mg/kg；灌胃；每日；妊娠第6至15天）在Wistar大鼠中给予50或250 mg/kg的组别表现出母体毒性。在雄性和雌性大鼠中，Glufosinate ammonium（口腔插管）在血液中的排除半衰期少于4小时[3]。 |
| molecular weight | 198.16 |
| Molecular formula | C5H15N2O4P |
| CAS | 77182-82-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 250 mg/mL (1261.61 mM), Sonication is recommended. |
| References | 1. Feat-Vetel J, et al. Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology. 2018 Dec;69:152-163. 2. Ebert E, et al. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol. 1990 May;28(5):339-49. 3. Áy Z, et al. The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene. ScientificWorldJournal. 2012;2012:657945. |