| Description | GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM). |
| molecular weight | 419.38 |
| Molecular formula | C16H16F3N3O5S |
| CAS | 2055015-61-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 270 mg/mL (643.81 mM), Sonication is recommended. |
| References | 1. Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221. |