| Description | GLP-26, an HBV capsid assembly regulator (CAM), inhibits HBV DNA replication (IC50=3 nM) in the Hep AD38 system and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pregenomic RNA, leading to nucleocapsid disassembly and reducing the cccDNA library. |
| In vitro | 给予HepNTCP-DL细胞0.7-1.7 μM GLP-26连续3天，可以降低转染有HBV野生型的细胞中分泌的HBeAg水平，其半数有效浓度(EC50)值为0.7 μM[1]。 |
| Target activity | HBV:0.7 μM(EC50), HBV:3 nM |
| molecular weight | 373.35 |
| Molecular formula | C19H17F2N3O3 |
| CAS | 2133017-36-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (267.85 mM), Sonication is recommended. |
| References | 1. Nijampatnam B, et al. Recent advances in the development of HBV capsid assembly modulators. Curr Opin Chem Biol. 2019 Jun;50:73-79. |