| Description | GLP-1(32-36)amide acetate is a pentapeptide and derived from the C terminus of the glucoregulatory hormone GLP-1. GLP-1(32-36)amide acetate could inhibit weight gain and modulate whole body glucose metabolism in diabetic mice. |
| In vitro | GLP-1(32-36)amide acetate（0.1-10 μM；24小时）在INS‐1细胞中对抗链脲佐菌素（STZ；1 μM）的作用下，能够保持细胞活性并减少细胞凋亡[1]。 |
| In vivo | GLP-1(32-36)amide acetate(1 μmol/kg; 腹腔注射，每天一次，连续21天)能够保护胰岛免受损害，抑制体重增加，并缓解糖尿照行鼠的多饮症状[1]。此外，GLP-1(32-36)amide acetate(1 μmol/kg; 单次腹腔注射)在正常小鼠中，使葡萄糖水平降低[1]。GLP-1(32-36)amide acetate(50-70 nmol/kg/d; 持续输注12-16周)能够预防高脂饮食小鼠发展成为肥胖和肝脂肪变性[2]。 |
| Synonyms | GLP-1(32-36)amide 醋酸盐, GLP-1(32-36)amide acetate(1417302-71-6 Free base) |
| molecular weight | 630.78 |
| Molecular formula | C27H54N10O7 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Sun L, et, al. Novel Pentapeptide GLP-1 (32-36) Amide Inhibits β-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. ChemBiol Drug Des. 2015 Dec;86(6):1482-90. 2. Tomas E, et, al. GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice. Diabetes. 2015 Jul;64(7):2409-19. |