| Description | GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain. |
| In vivo | GLN-1062在脑部的生物可用性比相同剂量的加兰他敏高出15倍以上。在药物诱导的健忘症动物模型中，与同等剂量的加兰他敏相比，GLN-1062能显著提高认知能力，且未显示出典型的未改性药物及其他胆碱酯酶抑制剂（如多奈哌齐和利伐斯汀）常见的显著胃肠道副作用。在雪貂模型中，使用GLN-1062代替加兰他敏时，明显减少了呕吐和行为反应[1]。 |
| molecular weight | 391.46 |
| Molecular formula | C24H25NO4 |
| CAS | 224169-27-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (114.95 mM) |
| References | 1. Maelicke A, et al. Memogain is a galantamine pro-drug having dramatically reduced adverse effects and enhanced efficacy. J Mol Neurosci. 2010 Jan;40(1-2):135-7. |