| Description | 1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively.3. Gitogenin shows moderate stimulation of release activity on growth hormone from rat pituitary cells. |
| Target activity | α-glucosidase:IC50 : 37.2 μM, UGT1A4:0.69 µM (IC50) |
| molecular weight | 432.64 |
| Molecular formula | C27H44O4 |
| CAS | 511-96-6 |
| Storage | store at low temperature,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.33 mg/mL (10 mM), Sonication is recommended. Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble |
| References | 1. Shim S , Lee E , Kim J , et al. Rat Growth-Hormone Release Stimulators from Fenugreek Seeds[J]. Chemistry & Biodiversity, 2008, 5(9):1753-1761. |