| Description | Giripladib (PLA695)(PLX-695) is a cPLA2-specific inhibitor that inhibits the radiation-induced increase of phosphorylated ERK and phosphorylated Akt in endothelial cells. |
| Synonyms | PLA 695, PLA-695, PLA695 |
| molecular weight | 745.25 |
| Molecular formula | C41H36ClF3N2O4S |
| CAS | 865200-20-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 7.45 mg/mL (10 mM) |
| References | 1. Duvernay MT, et al. Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation. Biochemistry. 2015 Sep 15;54(36):5578-88. 2. Thotala D, et al. Cytosolic phospholipaseA2 inhibition with PLA-695 radiosensitizes tumors in lung cancer animal models. PLoS One. 2013 Jul 19;8(7):e69688. |