| Description | GFB-12811 is a highly selective and orally active inhibitor of cyclin-dependent kinase 5 (CDK5), exhibiting an inhibitory concentration (IC50) of 2.3 nM. It demonstrates notable specificity, with minimal activity against other tested kinases, including CDK1, CDK2, CDK6, CDK7, and CDK9 [1]. |
| molecular weight | 449.44 |
| Molecular formula | C22H23F4N5O |
| CAS | 2775311-17-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |