Gemigliptin Tartrate(911637-19-9 free base) Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties.
In vitro	Gemigliptin tartrate通过抑制AGE-BSA的形成，其IC50为11.69 mM[1]。此外，Gemigliptin tartrate还能抑制预形成的AGE-BSA与大鼠尾腱胶原的交联，IC50为1.39 mM[1]。Gemigliptin tartrate是一种具有7.25 nM Ki值的竞争性DPP-4抑制剂[2]。
In vivo	Gemigliptin tartrate 在体内抑制了AGEs的形成以及AGE交联[1]。Gemigliptin tartrate 以剂量依赖的方式抑制了大鼠、狗和猴子的血浆DPP-4活性[2]。
Target activity	DPP4 (human recombinant):10.3 nM
Synonyms	吉格列汀酒石酸盐, LC15-0444 tartrate
molecular weight	639.45
Molecular formula	C22H25F8N5O8
CAS	1374639-74-3
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	DMSO: 90 mg/mL (140.75 mM), Sonication is recommended.
References	1. Jung E , Kim J , Kim S H , et al. Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo.[J]. European Journal of Pharmacology, 2014, 744:98-102. 2. Kim S H , Jung E , Yoon M K , et al. Pharmacological profiles of gemigliptin (LC15-0444), a novel dipeptidyl peptidase-4 inhibitor, in vitro and in vivo[J]. European Journal of Pharmacology, 2016, 788:54-64.

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