| Description | Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib. |
| Target activity | Tyr1173 site (NR6wtEGFR cells):37 nM , Tyr992 site (NR6wtEGFR cells):37 nM |
| Synonyms | ZD1839 D8, Gefitinib D8 |
| molecular weight | 454.95 |
| Molecular formula | C22H24ClFN4O3 |
| CAS | 857091-32-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23. 2. Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8. |