| Description | GDC-2394, an orally active, selective NLRP3 inhibitor, also targets IL-1β, exhibiting inhibitory concentrations (IC50s) of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). It effectively hampers NLRP3-induced caspase-1 activity while not affecting NLRC4-dependent inflammasome activation. |
| molecular weight | 431.51 |
| Molecular formula | C20H25N5O4S |
| CAS | 2238822-07-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |