| Description | GCN2-IN-1 (A-92) is an effective GCN2 inhibitor and can be used in research on the treatment of cancer as a chemotherapeutic agent. |
| In vitro | GCN2-IN-1 inhibits GCN2 with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay[1]. |
| Target activity | GCN2:<0.3 μM |
| Synonyms | A-92 |
| molecular weight | 402.41 |
| Molecular formula | C19H18N10O |
| CAS | 1448693-69-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (136.68 mM), Sonication is recommended. |
| References | 1. Dieter Dorsch, et al. Triazolo[4,5-d]pyrimidine derivatives. WO2013110309A1. |