| Description | GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 200 nM and 35 nM for hTRα and hTRβ, respectively. |
| In vitro | GC 14 contains extensions at the 5′-position of the outer thyronine ring or from the bridging carbon and has only a modest affinity and potency for the thyroid hormone receptor (TR). |
| Target activity | TRα (human):200 nM , TRβ (human):35 nM |
| molecular weight | 449.5 |
| Molecular formula | C26H27NO6 |
| CAS | 447415-34-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Koehler K, et al. Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7. 2. Chiellini G, et al. Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem. 2002 Feb;10(2):333-46. 3. Nguyen NH, et al. Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20. |