| Description | Gatipotuzumab (PankoMab), a humanized monoclonal antibody, targets the tumor-specific epitope TA-MUC1 of mucin-1 and exhibits potent tumor-specific antibody-dependent cell cytotoxicity (ADCC) [1] [2]. |
| In vitro | Gatipotuzumab（PankoMab）在PDTRP序列上T位点被GalNAcα糖基化时，可强烈结合由30个氨基酸构成的短MUC1肽（1.5 TRs），但在未糖基化的相同肽上不结合。在（1 h）情况下，Gatipotuzumab（PankoMab）对肿瘤细胞表现出高亲和力，其K D 值分别为NM-D4细胞的0.91 nM、ZR75-1细胞的3.03 nM、MCF-7细胞的3.84 nM以及T-47D细胞的7.14 nM。在（0-5 μg/mL; 4 h）条件下，Gatipotuzumab（PankoMab）展现出特异性的抗肿瘤抗体依赖性细胞毒性活性。 |
| Synonyms | PankoMab |
| molecular weight | N/A |
| CAS | 1264737-26-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years |