| Description | Gastrazole, a CCK2 receptor antagonist, is used potentially for the treatment of pancreatic cancer. |
| Synonyms | JB-95008, JB95008, JB 95008, Gastrazole sodium |
| molecular weight | 689.652 |
| Molecular formula | C34H34FN5Na2O7 |
| CAS | 862583-15-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Harper EA, Mitchell EA, Griffin EP, Kalindjian SB. Thermodynamic analysis does not allow discrimination of agonists and antagonists at human CCK2S-receptors. Eur J Pharmacol. 2008 Feb 26;581(1-2):1-12. PubMed PMID: 18158148. 2. Harper EA, Roberts SP, Kalindjian SB. Thermodynamic analysis of ligands at cholecystokinin CCK2 receptors in rat cerebral cortex. Br J Pharmacol. 2007 Aug;151(8):1352-67. PubMed PMID: 17592503; PubMed Central PMCID: PMC2189820. 3. Chau I, Cunningham D, Russell C, Norman AR, Kurzawinski T, Harper P, Harrison 4. P, Middleton G, Daniels F, Hickish T, Prendeville J, Ross PJ, Theis B, Hull R, Walker M, Shankley N, Kalindjian B, Murray G, Gillbanks A, Black J. Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br J Cancer. 2006 Apr 24;94(8):1107-15. PubMed PMID: 16622436; PubMed Central PMCID: PMC2361246. |