Description | Ganoderic acid F inhibits the proliferation of HeLa human cervical carcinoma cells with IC(50) values of 19.5+/-0.6 microM. |
In vitro | Ganoderic acid F 具有抗肿瘤和抗转移特性,其机制主要通过抑制血管生成以及改变涉及细胞增殖和/或细胞死亡、致癌作用、氧化应激、钙信号传导和内质网应激的蛋白表达。Ganoderic acid F 属于伽诺德酸类化合物。 |
Target activity | Proliferation:19.5±0.6 μM |
molecular weight | 570.67 |
Molecular formula | C32H42O9 |
CAS | 98665-15-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility | DMSO: 100 mg/mL (175.23 mM) |
References | 1. Yue QX, et al. Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells. Phytomedicine. 2010 Jul;17(8-9):606-13. 2. Teekachunhatean S, et al. Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers. Evid Based Complement Alternat Med. 2012;2012:780892. |