| Description | γ-Glu-Gly (gamma-Glutamylglycine), a γ-glutamyl dipeptide, is a human lipid metabolite with a structure resembling that of GABA (γ-aminobutyric acid). It functions as an antagonist of excitatory amino acids. |
| In vitro | γ-Glu-Gly 在陈年奶酪的风味形成中扮演了至关重要的角色。在 S. cerevisiae 中，γ-谷氨酰转移酶 (GGT) 可生成两种γ-谷氨酰肽，即 γ-Glu-Glu 和 γ-Glu-Gly。[1] |
| In vivo | Gamma-glutamylglycine (200 ng; seizure activity was elicited electrically from the inferior colliculus) significantly elevated the threshold current for seizure production.[4] |
| Synonyms | gamma-Glutamylglycine |
| molecular weight | 204.18 |
| Molecular formula | C7H12N2O5 |
| CAS | 1948-29-4 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 4.5 mg/mL (22.0 mM), Sonication is recommended. DMSO: < 1mg/ml (insoluble） |
| References | 1. Kit-Yi Leung, et al. Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia. J Inherit Metab Dis. 2020 Nov;43(6):1186-1198. 2. Sonu Yadav, et al. Metabolomics shows the Australian dingo has a unique plasma profile. Sci Rep. 2021 Mar 4;11(1):5245. 3. Olga A Sofyanovich, et al. Multiple pathways for the formation of the γ-glutamyl peptides γ-glutamyl-valine and γ- glutamyl-valyl-glycine in Saccharomyces cerevisiae. PLoS One. 2019 May 9;14(5):e0216622. 4. McCown TJ, et al. Amino acid influences on seizures elicited within the inferior colliculus. J Pharmacol Exp Ther. 1987;243(2):603-608. 5. Nicoletti F, et al. The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells. J Neurosci. 1986;6(7):1905-1911. |