γ-1-MSH, amide acetate (72629-65-3 free base) Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	γ-1-MSH, amide acetate (72629-65-3 free base), a putative hormone in the N-terminal region of the ACTH/beta- endorphin (beta-EP) precursor protein, was studied by RIA with an antiserum against gamma 3-MSH in ACTH-producing mouse pituitary tumor cells, AtT-20/D16v.
In vitro	γ-Melanocyte Stimulating Hormone (γ-MSH) 调节包括能量稳态、食物摄取、钠 (Na+) 平衡和血压调节在内的多种代谢功能。γ-MSH 由垂体腺中的前体激素 pro-opio-melanocortin (POMC) 加工处理而来，其中的组分肽释放到脑脊液和全身循环中。γ-MSH 的天然受体是 melanocortin receptor 3 (MC3-R)，一种激活腺苷酸环化酶的G蛋白偶联受体，在大脑（下丘脑、皮质、丘脑）、肠道、胎盘和肾上表达。在高盐饮食条件下，γ-MSH 通过诱导尿钠排泄（利尿作用）来调节 Na+ 平衡[1]。
Synonyms	γ-1-MSH, amide acetate
molecular weight	1572.81
Molecular formula	C74H101N21O16S
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	DMSO: 10 mM
References	1. Kathpalia PP, et al. The natriuretic mechanism of Gamma-Melanocyte-Stimulating Hormone. Peptides. 2011 May;32(5):1068-72.

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