| Description | Gadopentetic acid (gadolinium complex) (Gd-DTPA) is an paramagnetic contrast agent commonly implemented by a bolus intravenous injection (i.v.) in Dynamic contrast-enhanced MRI (DCE-MRI) studies. |
| In vivo | 在DCE-MRI中，Gadopentetic acid（Gd-DTPA）在血浆中的初始浓度（[Gd-DTPA0]）是一个重要参数。[Gd-DTPA0]取决于给药的脉冲剂量且会因受试者而异。使用0.025 mmol/kg Gd-DTPA的脉冲剂量，可以缩短获取时间，减少受试者的暴露量，其半衰期为37.3分钟，平均滞留时间为53.8分钟，以及AUC为3.37 ± 0.47 mmol/min/L。 |
| Synonyms | gadolinium complex, 钆喷酸, Gd-DTPA |
| molecular weight | 547.57 |
| Molecular formula | C14H20GdN3O10 |
| CAS | 80529-93-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 100 mg/mL (182.63 mM), Sonication is recommended. DMSO: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Wan C, et al. Gd-DTPA-induced dynamic metabonomic changes in rat biofluids. Magn Reson Imaging. 2017 Dec;44:15-25. 2. Taheri S, et al. Analysis of pharmacokinetics of Gd-DTPA for dynamic contrast-enhanced magnetic resonance imaging. Magn Reson Imaging. 2016 Sep;34(7):1034-40. |