| Description | GABAA Receptor Agent 5 (compound 018) serves as a potent γ-GABAAR antagonist, possessing a Ki of 0.020 μM. This compound exhibits γ-GABAAR antagonist properties, yet it demonstrates low cellular membrane permeability [1]. |
| In vitro | GABAA receptor agent 5 (compound 018) shows antagonist activity with IC 50 s of 0.24, 0.088, 0.068, 0.33, 0.79, 0.32, 0.079, 0.051 μM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively [1]. |
| molecular weight | 383.51 |
| Molecular formula | C21H25N3O2S |
| CAS | 1808389-92-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |