| Description | G43 is a potent and selective glucosyltransferase inhibitor that inhibits GtfB and GtfC with Kd values of 3.7 μM and 46.9 nM, respectively.G43 exhibits in vitro and in vivo anti-Streptococcus mutans activity and can be used for caries studies. |
| In vitro | G43 (16 h) inhibits Streptococcus mutans biofilm by 85% at a concentration of 12.5 μM.[1] G43 (25 μM; 24 h) reduces glucan production by glycosyltransferase (Gtfs) and continuously inhibits the activities of GtfB and GtfC, with an inhibition rate of 80% for both enzymes.[1] G43 (25 μM; 24 h) has no significant effect on the expression of gtfs (gtfB, gtfC and gtfD) in UA159 mutans Streptococcus mutans.[1] G43 (50 μM; 24-48 h) reduces biofilm formation by reducing the production of water-insoluble exopolysaccharides in wild-type Streptococcus mutans.[2] |
| In vivo | G43（100 µM；每日两次局部给药，为期4周；实验对象为感染S. mutans UA159的大鼠）能减少Streptococcus mutans的致病性，但在研究期间体重并未减轻。[1] |
| Synonyms | G 43, G-43 |
| molecular weight | 341.34 |
| Molecular formula | C16H11N3O4S |
| CAS | 690693-02-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (131.83 mM) |