| Description | G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS). |
| Target activity | cGAS (mouse):442 nM, cGAS (human):14 nM |
| molecular weight | 379.24 |
| Molecular formula | C17H16Cl2N4O2 |
| CAS | 2369751-07-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 247 mg/mL (651.30 mM), Sonication is recommended. |
| References | 1. Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261. |