| Description | G-1749 does not alter the monomer-dimer equilibrium of IRE, stimulates the RNase activity of unphosphorylated IRE1 and inhibits IRE1-3P, and significantly increases the RNase activity of IRE1-KR-0P. |
| Synonyms | G1749, G 1749 |
| molecular weight | 498.59 |
| Molecular formula | C28H30N6O3 |
| CAS | 2245057-57-0 |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Ferri E, et al. Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands. Nat Commun. 2020 Dec 14;11(1):6387 |