| Description | FTase-IN-1 (compound 17a) is a highly effective inhibitor of fanesyl transferase (FTase), exhibiting a remarkable IC50 value of 0.35 μM. This compound demonstrates significant cytotoxicity potential and exhibits powerful antitumor activity [1]. |
| In vitro | FTase-IN-1 (compound 17a) (10 μM, 48 h) is an inhibitors of farnesyl transferase (FTase) and inhibits NCI-60 cells proliferation in vitro [1]. FTase-IN-1 (10 μM, 48 h) arrests the cell growth of multiple cancer cell lines with GI 50 range from 1.8 to 6.5 nM [1]. Cell Viability Assay [1] Cell Line: NCI-H522 (lung cancer), COLO-205 and HT29 (colon cancer), SF-539 (human glioblastoma), MDA-MB-435 (melanoma), OVCAR-3 (ovarian cancer) and A498 (renal cancer) Concentration: 10 μM Incubation Time: 48 hours Result: Inhibited cell growth and showed strong antitumor activity. |
| molecular weight | 384.45 |
| Molecular formula | C23H16N2O2S |
| CAS | 2490538-41-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |