| Description | Fructosyl-lysine is the precursor to glucosepane. Fructosyl-lysine is a lysine–arginine protein cross-link that can be an indicator in diabetes detection. Fructosyl-lysine is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. |
| In vitro | Fructosyl-lysine (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in?E?.coli extracts. Fructosyl-lysine (25 mM; 25 hours) lets E. coli?growth at a rate of about one-third of that observed with glucose as a carbon source. Fructosyl-lysine (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products showing the existence of a fructoselysine-kinase activity in E?.coli extracts [2]. |
| In vivo | In diabetic rats, Fructosyl-lysine and AGE residues are increased markedly in glomeruli, sciatic nerve, retina, and plasma protein [1]. |
| Synonyms | Fructoselysine, 果糖-赖氨酸 |
| molecular weight | 308.33 |
| Molecular formula | C12H24N2O7 |
| CAS | 21291-40-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Rabbani N, et al. Hidden complexities in the measurement of fructosyl-lysine and advanced glycation end products for risk prediction of vascular complications of diabetes. Diabetes. 2015 Jan;64(1):9-11. 2. Karachalias N, et al. Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem Soc Trans. 2003 Dec;31(Pt 6):1423-5. |