| Description | possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa, |
| In vitro | Frondoside A (0-5 μM, 24 hours)causes concentration-dependent reduction in viability of lung and breast cancer cells through a caspase 3/7-dependent cell death pathway. |
| In vivo | Frondoside A (0.01 and 1 mg/kg/ day i.p. for 25 days) significantly decreases the growth, the lymph node metastasis?and angiogenesis of LNM35 tumor xenografts in mice, without obvious toxic side-effects. |
| molecular weight | 1336.45 |
| Molecular formula | C60H96NaO29S |
| CAS | 127367-76-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Sajwani FH, et al. Frondoside A is a potential anticancer agent from sea cucumbers. J Cancer Res Ther. 2019 Jul-Sep;15(5):953-960. 2. Attoub S, et al. Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis. PLoS One. 2013;8(1):e53087. |