| Description | Framycetin sulfate (Neomycin Sulphate B) belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds. |
| Target activity | Hammerhead ribozyme:13.5 μM (Ki), RNase P cleavage activity:35 μM (Ki) |
| Synonyms | Neomycin Sulphate B, 硫酸新霉素B, Framycetin sulphate |
| molecular weight | 712.22 |
| Molecular formula | C23H48N6O17S |
| CAS | 4146-30-9 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 125 mg/mL (175 mM） DMSO: Insoluble |
| References | 1. Quader, S., Boyd, S., Jenkins, I., & Houston, T. (2007). Multisite Modification of Neomycin B: Combined Mitsunobu and Click Chemistry Approach. The Journal Of Organic Chemistry, 72(6), 1962-1979. doi: 10.1021/jo0620967 2. Li J, Fan Y Y, Wang M, et al. A Light-Up Strategy with Aggregation-Induced Emission for Identification of HIV-Ι RNA-Binding Small Molecules[J]. Analytical Chemistry. 2020 |
| Citations | 1. Li J, Fan Y Y, Wen J, et al. Metal-Enhanced Aggregation-Induced Emission Strategy for the HIV-I RNA-Binding Ligand Assay. Analytical Chemistry. 2022 2. Li J, Fan Y Y, Wen J, et al. Metal-Enhanced Aggregation-Induced Emission Strategy for the HIV‑I RNA-Binding Ligand Assay. Analytical Chemistry. 2022, 94(11): 4695-4702 3. Li J, Fan Y Y, Wang M, et al. A Light-Up Strategy with Aggregation-Induced Emission for Identification of HIV-Ι RNA-Binding Small Molecules. Analytical Chemistry,. 2020 |