| Description | FR901464 (WB 2663B) is potent cytotoxic natural products that share an amine-containing tetrahydropyran ring. |
| In vitro | FR901464（10-20 ng/ml；6-24小时）抑制了小鼠固体肿瘤、结肠癌和methoxamine A肉瘤的生长。FR901464通过与SV40启动子依赖的细胞转录相同的原理，诱导M-8肿瘤细胞周期中特有的G1及G2/M期阻滞以及基因组DNA的核间裂解。FR901464（1-10 ng/ml）在M-8细胞中诱导了一些内源性基因的转录，但未抑制内源性基因的转录[1]。 |
| Synonyms | FR 901464, FR-901464, WB 2663B |
| molecular weight | 507.62 |
| Molecular formula | C27H41NO8 |
| CAS | 146478-72-0 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 90.0 mg/mL (177.3 mM), Sonication is recommended. |
| References | 1. Satoh T, Kaida D. Upregulation of p27 cyclin-dependent kinase inhibitor and a C-terminus truncated form of p27 contributes to G1 phase arrest. Sci Rep. 2016 Jun 10;6:27829. 2. Pham D, et, al. Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1. Nat Prod Rep. 2016 May 4;33(5):637-47. 3. He HY, et, al.An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing α-ketone in polyketide starter unit biosynthesis. Angew Chem Int Ed Engl. 2014 Oct 13;53(42):11315-9. doi: 10.1002/anie.201406602. Epub 2014 Aug 27. 4. Ghosh AK, et, al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79(12):5697-709. |